Madhusudan Gupta had significant contribution to the history of Calcutta Medical College (CMC) and hospital. During the prima stage of medical college, Indian students were not coming to join the course partly because they were from aristocratic Indian families who had disdain for surgery (reluctant to touch the dead body) and partly because the Ayurvedic and Unani systems of medicine were popular at that time. He was a Sanskrit scholar and Ayurvedic doctor and he did proclaim that he will dissect the dead body and that created waves among the people and after that many came to join the medical education at CMC. The British government fired 50 cannon shot to honour him. The government was happy because they broke past the custom thought prevailing there to some extent which in fact went against "The Native Medical Institution (NMI)" which was practicing Ayurvedic and Unani medicine culture without any scientific basis. He was one among the first batch of students passed from the CMC.